Negative design of foldable proteins : new algorithm
نویسندگان
چکیده
منابع مشابه
Prebiotic protein design supports a halophile origin of foldable proteins
There are significant challenges in forming testable hypotheses regarding abiogenesis (i.e., the origin of life); for example, the original environment on the early Earth during the process of abiogenesis is a matter of debate [although it was significantly different from the current environment (Oparin, 1952; Hazen et al., 2008)]. Furthermore, the process of abiogenesis occurred over a time sc...
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چکیده ندارد.
15 صفحه اولNegative design for improved therapeutic proteins.
Future directions In the near future, it might be interesting to investigate the behavior of p27 with (partial) flexibility in the cyclin A – CDK2 complex, and eventually compare this with high temperature molecular dynamics simulations. Because the structural details of coupled folding and binding for intrinsically disordered proteins are not clear, we anticipate additional simulation studies,...
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Print-and-fold manufacturing has the potential to democratize access to robots with robots that are easier to fabricate using materials that are easier to procure. Unfortunately, a lack of understanding about how motion can be achieved by folding hinders the scope of print-and-fold robots. In this paper, we show how the basic joints used in robots can be constructed using print-and-fold. Our pa...
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In this paper, design and simulation of a new highly sensitive gas sensor based on a hybrid photonic crystal (PC) structure, containing negative and positive refractive index sections, is presented. It has been shown that using a PC with negative refraction in the first section, the transmitted power is concentrated on the entrance of the sensing channel, and the transmission of the proposed se...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2003
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.43.s78_1